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Formulation development & evaluation floating microsphere by using natural polymer & HPLC Method development
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Author's Name: Nilima Thombre1, Atul Bagdane2, Navnath Thakre3, N,,,

AuthorsAbstractReferencesKeywords

Authors: Nilima Thombre1, Atul Bagdane2, Navnath Thakre3, N,,,
Branch: General Science
Volume: VOLUME - 9
Album: Issue-6 , June -2018

ABSTRACT:The current research work developed multiparticulate drug delivery system of OndansetronHCl based sustained release dosage form using natural polymers such as sodium alginate and tamarind gum by ionotropic gelation technique with application of calcium chloride solution as crosslinking agent and studied effect of polymer concentration on release profiles formulations. The formulations were developed using 32 full factorial designs using sodium alginate and TSP in various ratios keeping amount of drug constant. Developed Microsphere were evaluated for characteristics like micrometrics properties percentage yield, DSC, XRD, FTIR, drug entrapment efficiency, in-vitro buoyancy, in-vitro drug release study. Developed microsphere possess % yield of 96 to 98,drug release of, entrapment efficiency of 71 to 98,Drug release of 71 to 99 %. The formulation was evaluated by HPLC method. Thus the developed formulation of floating drug delivery systems was found to be an efficient and potential approach for gastric retention of dosage forms to improve bioavailability and achieved controlled release dosage form.

KEYWORDS-Ondancetron HCL, Floating microsphere, Tamarind seed polysaccharide, Sodium alginate, Ionotropic gelation.

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